Antioxidant and hepatoprotective effects of benth against paracetamol and ccl induced liver damage in rats

Abstract

Hepatic diseases are flattering ordinary day by day and pose grave health threats to the life of humans. In sort to treat these diseases, the awareness of man is diverting towards herbal drugs, which are much safer and cost effectual than synthetic drugs. The aspire of this work was to explore antioxidant and hepatoprotective activity of ethanolic and aqueous extract of () bark for treatment of liver damage induced by CCland paracetamol (PCM) in rats. In vitro antioxidant activities aqueous and ethanolic extracts were also checked using 1-1-diphenyl-2-picryl hydrazine (DPPH), nitric oxide (NO), ABTS scavenging method. at chosen oral doses of 250 mg/kg and 500 mg/kg levels of serum marker enzymes such as ALP, SGPT, SGOT, total bilirubin and direct bilirubin was reduced which indicate major hepatoprotective effects, when contrasted with silymarin and negative control. All the parameters wereobserved at oral dose of 500 mg/kg with extreme effects. The significant anti-oxidant activity was also demonstrated by the extracts. The preliminary screening of phytochemical indicates the presence of phenolics, tannins, flavonoids, carbohydrate and phytosterols. It is conceivable that extract of has activity of hepatoprotective against CCland paracetamol induced hepatotoxicity, due to the scavenging of free radical mechanisms demonstrated by phenolics and flavonoids, thus asserting its medicinal therapeutic role in liver diseases.