Antioxidant and antimicrobial potentials of biosynthesized Ag-Doped Ni-MOF as a novel hybrid nanocomposite

Abstract

Metal-organic frameworks (MOFs) are organic–inorganic crystalline compounds that have attracted much attention due to their wide range of applications. Bimetallic MOFs offer more possibilities than MOFs based on single metal. This study focuses on the synthesis and characterization of a Ni-MOF doped with silver nanoparticles (Ag NPs) as potent antioxidant and antimicrobial agent. Red cabbage extract was used as a reducing agent to synthesize Ag NPs. Ag@Ni-MOF nanocomposite exhibited significant growth inhibition of bacteria and fungi, and demonstrated the best antioxidant properties among the synthesized compounds. These results suggest that designed Ag@Ni-MOF nanostructure can be applied in the treatment of oxidative stress-related diseases as well as bacterial/fungal infections.