Abstract
The hypercaloric diet leads to obesity which is a risk factor for developing many systemic diseases such as diabetes, cardiovascular diseases and cancer. The purpose of our study was to observe the antioxidants effects of entrapped alfa-tocopherol (vitamin E) and lutein in Poly Lactic-CO-Glycolic acid (PLGA) in Wistar rats that received 3 weeks hypercaloric diet. Hepatic and splenic lysates have been used to detect changes in total antioxidant capacity (TAC) and advanced oxidative protein products (AOPP). The AOPP liver levels were statistically decreased in the case of rats groups that received a daily dose of PLGA-lutein or PLGA-vitamin E versus the control group. The AOPP level was decreased but statistically insignificant in Wistar rats spleen who received a daily dose of PLGA-lutein. At hepatic level, TAC was statistically increased in rats groups that received a daily dose of vitamin E or lutein. An increased statistical level of TAC was observed in the spleen cell lysing in Wistar rats who received the daily dose of PLGA-vitamin E. Entrapment of vitamin E and lutein in PLGA structure has diminished the effects of hypercaloric diet and can be considered a attractive and promising approach to enhance the bioavailability and activity of poorly water soluble compounds.
Highlights
The hypercaloric diet leads to obesity which is a risk factor for developing many systemic diseases such as diabetes, cardiovascular diseases and cancer
The main aim of our study was to observe the antioxidant effects of vitamin E and lutein entrapped in Poly Lactic-CO-Glycolic acid (PLGA) nanoparticles in Wistar rats that received the hypercaloric diet for 3 weeks
Increased glucose concentration actives polyol pathway, nicotinamide adenine dinucleotide phosphate (NADPH) is activated and reduces glucose to sorbitol and superoxide anion is produced in the endothelium[12]
Summary
The hypercaloric diet leads to obesity which is a risk factor for developing many systemic diseases such as diabetes, cardiovascular diseases and cancer. The main aim of our study was to observe the antioxidant effects of vitamin E and lutein entrapped in PLGA nanoparticles in Wistar rats that received the hypercaloric diet for 3 weeks. -Group 1 received the standard diet and a daily dose of nanoparticles PLGA (50mg/kg body weight)
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