Abstract
Gynostemma pentaphyllum Makino is a well known edible and medicinal plant in oriental countries, its dominant active constituents are mainly Gypenosides(GP). Endophytic fungi with antioxidant activity were screened and identified from gynostemma pentaphyllum, and gynostemma pentaphyllum saponin (GP) was used as host. A total of 10 strains of endophytic fungi were isolated from the root of healthy, living, and symptomless tissues of Gynostemma pentaphyllum Makino. The extract from a strain (G4) showed antioxidant activity and had the same RF value in TLC, because the retention time of real gynostemma pentaphyllum saponin (GP) and its extract was the same as that of natural gynostemma pentaphyllum (GP) in HPLC. So the strain G4 of endophytic fungus appears to produce the same components as its host.
Highlights
Gynostemma pentaphyllum Makino is a well known edible and medicinal plant in oriental countries[1,2], and is known as ‘Jiao-Gu-Lan’ in China, ‘‘Cha-Satun” in Thailand, and ‘‘Amachazuru” in Japan[3]
Gynostemma pentaphyllum Makino has attracted great attention owing to its anti-tumor activities[4], immunomodulatory effect[5], anti-gastric ulcer effect, treating hyperlipidemia, and anti-oxidant properties[6], and has been described as having minimal toxicity[7]
Ten endophytic fungal strains were isolated from the roots of Gynostemma pentaphyllum Makino
Summary
Gynostemma pentaphyllum Makino is a well known edible and medicinal plant in oriental countries[1,2], and is known as ‘Jiao-Gu-Lan’ in China, ‘‘Cha-Satun” in Thailand, and ‘‘Amachazuru” in Japan[3]. Gynostemma pentaphyllum Makino has attracted great attention owing to its anti-tumor activities[4], immunomodulatory effect[5], anti-gastric ulcer effect, treating hyperlipidemia, and anti-oxidant properties[6], and has been described as having minimal toxicity[7]. Endophytes are a kind of inadequately studied microorganisms, which are rich and reliable sources of biological activities and new chemical compounds. Fungal endophytes are considered to be repositories of new secondary metabolites, some of which have beneficial biological activities. Recent studies have shown that fungal endophytes are ubiquitous in plant species[10]
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