Abstract
The effect of Gypenosides, an active component of Chinese herbs Gynostemma Pentaphyllum (Thumb) Makino, on human hepatoma cell line (Huh 7) was investigated. Results demonstrated that Gypenosides inhibited the proliferation or viability of the Huh 7 cells in a dose-dependent manner. The Huh 7 cells treated with Gypenosides for two days caused a less DNA stainable and formed sub-G1 peak, increased the cell numbers in the A0 region, shifted the ordinary S phase to the last S phase (D1 region) and induced a ladder pattern of fragmented DNA about 200 base pairs. It suggest that the cell death of hepatoma cells line Huh 7 induced by Gypenosides were via apoptosis, which was also confirmed by the morphological study.
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