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Abstract
Oximes of isoxanthohumol (IXN), naringenin (N) and flavanone (FL) were synthesized with yields of 88–95% and their antioxidant activity was evaluated using the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) method. Although naringenin oxime (NOX) and flavanone oxime (FLOX) did not have any significant antioxidant effect (EC50=2.21mM and 78.7mM, respectively), isoxanthohumol oxime (IXNOX) showed a strong antioxidant activity (EC50=0.0411mM), comparable to the activity of ascorbic acid (EC50=0.0181mM). The structure of new compound IXNOX was established using 1H NMR, 13C NMR, IR and UV–VIS spectroscopy, by comparison to IXN, NOX and FLOX.
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Schedule a callMore From: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
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