Abstract
BackgroundOxidative stress and related diseases resulting from the overproduction of free radicals can be counteracted by designing and developing novel antioxidative agents that can protect the human body against the damage caused by free radicals.MethodsThe present study evaluated the antioxidant activities of 15 derivatives of 2-thioxobenzo[g]quinazoline using three different assays: 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, reducing power capability, and ferric reduction antioxidant power.ResultsSome benzoquinazolines had good activity and had the capacity to deplete DPPH and free radicals compared to a positive control butylated hydroxyl toluene (BHT). A docking study identified the possible interactions between binding models and the antioxidant activities of the target compounds.ConclusionsThe active compounds can be used as templates for further development of more potent antioxidative agents.
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