Abstract
Purpose In the present investigation a series of coumarin derivatives (CDs) were evaluated for their in vitro antioxidant and anticancer activities. This study was to assess the suitability of a series of structurally different CDs as possible antioxidant and anticancer agents. Methods The antioxidant studies were carried out using a 2,2,-diphenyl-1-picrylhydrazine (DPPH) radical scavenging assay, while the anticancer activity was assessed by performing the (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliuum bromide-based (MTT-based) cytotoxicity assay using different cancer cell lines. The physico-chemical properties of the test CDs related to free radical scavenging reactions and other biological properties were also calculated using BioMed Cache 6.1.10. Result Selected CDs showed significant cytotoxicity against different cancer cell lines in an IC 50 range of 7.51–17.48 μM. All the selected CDs were demonstrated to have considerable concentration-dependent DPPH radical scavenging activity. Conclusion These results may signify the importance of selected CDs as antioxidant and anticancer agents.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
