Antinociceptive, antipyretic and anti-inflammatory effects of Clerodendrum phlomidis in mice and rats

Abstract

The ethanolic extract of Clerodendrum phlomidis L. belonging to the family of Verbenaceae was evaluated for its antinociceptive, antipyretic and anti-inflammatory activity in mice and rats respectively. Analgesic activity was studied by using acetic acid-induced mouse withering test, hot water tail immersion method and eddy’s hot plate method in mice. The antipyretic activity was evaluated against yeast induced pyroxia in rat and anti-inflammatory activity was evaluated by carrageenan-induced hind paw edema and its probable mechanism evaluated in rats. The preliminary phytochemical screening and acute toxicity studies were carried out. C. phlomidis extract showed a dose dependent significant reduction of the number of writhes (P proteins, amino acids, phytosterols, alkaloids, fats, fixed oils, flavonoids and gums were present in the plant extract. It is clear that the ethanolic extract of C. phlomodis has significant analgesic and anti-inflammatory activity. Inhibition of the synthesis of prostaglandins and other inflammatory mediators probably account for the analgesic and anti-inflammatory properties. Key words: C. phlomidis , antinociceptive, antipyretic, anti-inflammatory, arthritis.