Abstract
Background: Phytosterols are commonly present in various plants, among which sitosterol is the abundant one. Various extracts of leaves of the plant were screened but a purified phytosterol like β-sitosterol (BS) is a compound of interest. Objective: The aim of the study is to evaluate for analgesic and anti-nociceptive property of activity BS. Materials and Methods: Hot plate test and Acetic acid-induced writhing’s test was used for evaluating the central and peripheral Antinociceptive activity and Anti-inflammatory activity was evaluated by carrageenan-induced hind paw edema method. Results: BS (10 and 20 mg/kg, i.p.) was responsible for the significant and dose-dependent activity comparable with the standard. Conclusion: The dose dependent activity of β-sitosterol might be responsible for analgesic and anti-inflammatory activity, this may also be a vital observation for further studies.
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