Abstract
Sesame oil is widely consumed as nutritious food, cooking oil, and in pharmaceuticals and food. In this study, the antinociceptive and anti-inflammatory properties of the sesame oil and sesamin were investigated. The sesame oil and sesamin reduced the number of abdominal contortions at the doses 100, 200, or 400 mg/kg. The first and second phases of the time paw licking were inhibited by sesame oil and sesamin (100, 200, or 400 mg/kg). After 90 min of treatment, sesame oil and sesamin increased the reaction time on a hot plate (200 or 400 mg/kg). Considering the tail-immersion assay, the sesame oil and sesamin produced significant effect after 60 min at the doses of 100, 200, or 400 mg/kg. After 4 h of application of the carrageenan, the sesame oil and sesamin were effective against the paw edema. The exudate volume and leucocyte migration were also reduced by sesame oil and sesamin. These results suggest that sesamin is one of the active compounds found in sesame oil and justify the antinociceptive and anti-inflammatory properties of this product.
Highlights
Among the natural constituents that have revealed antinociceptive and anti-inflammatory activities are reported compounds belonging to the fixed oils and lignans [1,2]
It was observed that the naloxone was able to inhibit the antinociceptive effects of sesamin and morphine, but was not able to inhibit the effect of the S. indicum oil
Our results revealed that the sesame oil and sesamin reduced the abdominal writhes induced by acetic acid showing antinociceptive effect
Summary
Among the natural constituents that have revealed antinociceptive and anti-inflammatory activities are reported compounds belonging to the fixed oils and lignans [1,2]. The oil of the Euterpe oleracea, with major compounds palmitic acid, palmitoleic acid and oleic acid [6], and palmitic acid derivatives [7], showed antinociceptive and anti-inflammatory effects Lignans, such as lariciresinol, taxiresinol, 3′-demethylisolariciresinol-9′-hydroxyisopropylether, isolariciresinol, and 3-demethylisolariciresinol isolated from Taxus baccata [2], as well as (+)-eudesmin, (+)-magnolin, (+)-yangambin, and epimagnolin B isolated from Magnolia fargesii [8] and phylligenin of Forsythia koreana [9] were able to inhibit inflammation and pain mechanisms in different biological models. In addition to being used as an emulsifier, the oil is rich in unsaturated fatty acids (palmitic, stearic, oleic, and linoleic acids) [14] and has anti-cholesterol property [15] It is widely consumed as nutritious food, very beneficial to health, as cooking oil, in pharmaceuticals, in shortening and margarine, as soap fat and as synergist for insecticides [16,17]. Properties, the present investigation was designed to evaluate the antinociceptive and anti-inflammatory activities of the sesame oil and sesamin
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