Abstract
The Ru(II) complexes of hydrazine derivatives of different 3-hydroxy 4-substituted flavones was synthesized to assess their biological activity. The ligand 2, 4 dinitrophenyl hydrazones of 3-hydroxy 4´-substituted flavones [where 4´-substituents are -OCH3(HL1), -NO2(HL2), NMe2(HL3), Cl (HL4), OCH2Ph (HL5)] were successfully coordinated with Ru(phen)2Cl2 which consists of the formula, [Ru(phen)2(HL1)]Cl2.2.5H2O (M1R), [Ru(phen)2(HL2)]Cl2(M2R), [Ru(phen)2(HL3)]Cl2(M3R), [Ru(phen)2(HL4)]Cl2.1.5H2O (M4R), [Ru(phen)2(HL5)]Cl2.1.5H2O (M5R). All the synthesized complexes were characterized by elemental analysis, IR, 1H-NMR, UV-Vis, and ESI-MS spectroscopic techniques. The geometry optimization of all complexes was carried by using Gaussian-09. All compounds were studied for antimycobacterial activity using Resazurin microtiter plate assay (REMA) followed by colony-forming unit (CFU) count. The metal complexes showed promising activity against M. smegmatis mc2. The DNA interaction of the complexes was also studied. These studies suggest that hydrazine derivatives of 3-hydroxy 4-substituted flavones and their Ru(II) complexes can be good candidates for antimycobacterial drug development studies.
Published Version
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