Antimicrobial susceptibility pattern of Gram-negative uropathogens at a tertiary care hospital in Gujarat

Abstract

Background and objectives: Urinary tract infections remain one of the most common infections in the community and susceptibility of uropathogens to commonly used antimicrobials has declined over the years. It is important to periodically study the antibiogram of uropathogens, so that empiric treatment can be determined using recent data and thus improving patient outcomes. The present study evaluated the antibiotic resistance trend of prevalent Gram-negative uropathogens in urine samples received at the microbiology laboratory at a tertiary care hospital. Material and methods: The study was conducted at the Department of Microbiology, Sir Takhtsinhji Hospital, Bhavnagar for one year period from March 2021 to February 2022. All received urine samples for culture and sensitivity were included in the study. All samples were subjected to culture and sensitivity using standard methods. Results: During study period, 918 (18.6%) organisms were isolated from 4938 urine samples. Out of 918, 85.1% (781) was Gram-negative and 9.8% was Gram-positive bacteria while 5.1% was Candida spp. Escherichia coli was the most prevalent (61.7%) of the total Gram-negative isolates. Gram-negative isolates were most resistant to amoxicillin/clavulanic acid, quinolones, trimethoprim/sulfamethoxazole. The rate of resistance to aminoglycosides, nitrofurantoin, third generation cephalosporins and carbapenems was comparatively low. Conclusion: Antimicrobial resistance of the prevalent uropathogens should be monitored routinely to plan effective empirical therapy. July 2024; Vol. 18(2):007. DOI: https://doi.org/10.55010/imcjms.18.019 *Correspondence:Kairavi Desai, Department of Microbiology, Government Medical College, Sir Takhtasinhji Hospital, Bhavnagar, Gujarat, India-364001. E-mail:drkairavi@yahoo.in