Abstract
The aim of the present study was to determine the sensitivity pattern of clinical isolates of otitis media. During the last few decades, the occurrence of otitis media seems to have been rising probably because of prevalence of multidrug-resistant Pseudomonas aeruginosa and β-lactamase producing Staphylococcus aureus in the pathogenesis of otitis media. Pseudomonas aeruginosa and Staphylococcus aureus were the most common causative microorganisms of ear infection. Keeping in view the importance of these pathogens, the present study had been designed to determine the sensitivity pattern of clinical isolates of otitis media. These isolates were collected from different hospitals and pathological laboratories of Karachi and their sensitivity against cefepime and amoxicillin were determined by using disk diffusion method. The results have shown that Pseudomonas aeruginosa was the most common causative microorganism of ear infection. Cefepime, a fourth generation cephalosporin appeared to be an effective antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus.
Highlights
The term Otitis media (OM) generally used to describe any inflammatory process involving the middle ear
The newer fourth generation cephalosporin, cefepime is effective against multidrug -resistant Pseudomonas aeruginosa and β-lactamase producing strains of Staphylococcus aureus
Antibiotic susceptibilities of clinical isolates from ear infection were summarized in Figures 1, 2, 3 and 4
Summary
The term Otitis media (OM) generally used to describe any inflammatory process involving the middle ear. The main categories of OM are 1) Acute Otitis Media (AOM), 2) Secretory otitis media (SOM), named chronic otitis media with effusion (COME) and 3) Chronic otitis media (COM) with or without cholesteatoma (Harkness and Topham 1998). Acute Otitis Media is a condition with acute middle ear effusion (MEE) and acute signs and symptoms of infection for example fever, pain, restless sleep, irritability, tugging or rubbing of ears. Secretory otitis media SOM (or COME) means that MEE has lasted at least 2–3 months behind intact tympanic membrane. A permanent perforation of tympanic membrane with recurrent or constant purulent discharge indicates COM.
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