Abstract
Aims: This Study is aimed at studying the Antimicrobial Resistance profile of Uropathogenic Escherichia coli isolated in Garaku, Keffi and Mararaban-gurku Healthcentres, Nasarawa-West Senatorial District, Nasarawa State, Nigeria. Study Design: is a survey research. Place and Duration of Study: Department of Microbiology, Nasarawa State University, Keffi, between June, 2021 and January,2024. Methodology: 384 urine samples of patients with suspected cases of UTIs were collected and E. coli was isolated and identified using standard microbiological methods. Antimicrobial Susceptibility Testing of the isolates was carried out in accordance with the Clinical and Laboratory Standards Institute (CLSI) method. Results: The occurrence of E. coli was 92(24%). The isolates were generally more resistant to Ampicillin (AMP) with 75.0%. Streptomycin (S) 70.7% Cefotaxime (CTX) 68.5% but less resistant to Ciprofloxacin (9.8%) followed by Gentamicin 17.4%. The commonest resistance phenotype was AMC-AMP-CAZ-CTX-S-SXT (5.4%). Most of the isolates showed multiple antibiotic resistance (MAR) Index of above 0.2 with the commonest MAR Index at GHK, GHG and MCM-g of 0.7(21.4%), 0.4(28.0%) and 0.3(23.1%) respectively. The antibiotics resistant E. coli isolates were grouped into different categories of antibiotic resistance namely: Non Multiple Drug Resistance (NMDR); Excessive Drug Resistance (XDR); Multiple Drug Resistance (MDR) and Pan Drug Resistance (PDR). The occurrence of classes of antibiotic resistance was of the orderMDR75(81.5%) ˃ NMDR9(9.8%) ˃XDR7(7.6%) > PDR 1(1.1%). Conclusion: with the results from this research, E. coli being non susceptible to many antimicrobials is a clear indication that, prescription of these antimicrobials by physicians and usage by patients must be done with diligence and utmost care and vigorous campaign by stakeholders must be step up to bring to the barest minimum incidences of Antimicrobial resistance.
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