Abstract
Antimicrobials are commonly used in animal production to prevent disease and promote growth. This practice puts the public’s health at risk by causing commensals living in the intestinal tracts of food animals to inevitably develop antimicrobial resistance. Cattle are common hosts of E. coli O157:H7 but the bacteria do not infect them. Human hemorrhagic colitis (HC) and hemolytic-uremic syndrome (HUS) are known to be caused by E. coli O157:H7. Antibiotics are a common therapy and have been chosen to treat HC and HUS. However, it is now known that the E. coli strain is resistant to a wide range of antibiotics. The goal of this study was to determine the resistance pattern of E. coli O157:H7 isolated from cattle in Cianjur, Sukabumi, and Lembang, West Java, Indonesia. A total of 62 isolates of E. coli were tested for susceptibility to 15 types of antibiotics using agar diffusion techniques. Test results showed that E. coli O157:H7 is resistant to Sulphamethoxazole, Cephalotin, Ampicillin, Nalidixic Acid, Amoxicillin/Clavulanic Acid, Streptomycin, Tetracycline, Kanamycin, Trimethoprim, Gentamycin, Norfloxacin, Enrofloxacin, Ciprofloxacin, and Amoxicillin. There are differences in multi-drug resistance among the local isolates of E. coli O157:H7 tested, which were resistant to antibiotics of the 1-5 type (79.03%), 6-10 type (4.84%), and 11-15 type (4.84%). In order to control the occurrence of multidrug antibiotic resistance and stop the spread of antibiotic-resistant foodborne pathogens to humans, it is necessary to monitor the use of antibiotics in cattle on farms.
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