Abstract
BackgroundFungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Antimicrobial peptides (AMPs) have been shown to play an important role on human ocular surface (OS)...
Highlights
Fungal keratitis (FK) is the commonest cause of corneal blindness in developing world
Informed consent was obtained from all patients prior to collection of samples, which included scrapes/ impression cytology from patients with active fungal keratitis, corneal buttons from patients that were subjected to therapeutic penetrating keratoplasty for fungal keratitis not responding to medical management and corneal tissue from patients with non-inflammatory corneal scar that underwent optical penetrating keratoplasty
A total 26 samples were collected. These included a part of corneal button (CB) (n=17), scrapings (n=5) and Impression cytology (IC) (n=4)
Summary
Fungal keratitis (FK) is the commonest cause of corneal blindness in developing world. Of patients that present with infective keratitis were culture positive for mycotic organisms[2 3]. The principal risk factor for FK in more than 70% of these cases was reported to be vegetative ocular injury[3]. Increasing reports of FK cases from countries with temperate conditions have added to the infection-related incidence of blindness globally[4,5,6]. Incidence of FK cases is increasing and mainly associated with contact-lens use and ocular trauma[7]. Fungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Our aim was to profile a spectrum of AMPs in corneal tissue from FK patients with active infection and after healing
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