Abstract
AbstractTo develop an antimicrobial membrane for wound healing, the blended k‐carrageenan (KC)/carboxymethyl chitosan (CMCH) membranes were fabricated through a freeze‐drying process together with a dual‐ion (Cu2+and K+ or Cu2+and Ca2+) crosslinking approach. The dual‐ion crosslinking by Cu2+and K+ could not only make the membranes compact but could also improve the uptake capacity and mechanical properties of the fabricated membranes. The maximum tensile stress of membranes reached up to 43 MPa and the highest swelling ratio was around 5500%, exhibiting robust moisture retention property. The CMCH and Cu2+ in blended membranes provided a good antimicrobial property against gram‐positive and gram‐negative bacteria. Moreover, the fabricated membranes showed good cytocompatibility. These results indicated the fabricated KC/CMCH membranes with dual‐ion by Cu2+ and K+ have favorable properties and have a great potential for application in wound healing.
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