Abstract
The main objective of the study was to evaluate antibacterial activity of Neem leaf extracts (methanolic) against E. coli and Salmonella using different test such as production performances, biochemical, hematological, bacteriological tests and zone of Inhibition (ZOI) method. Azadirachta indica (neem) leaf extract was used to test growth performance, biochemical , hematological parameters and antimicrobial activity against disease causing bacteria Escherichia coli and Salmonella. That’s result indicated, methanolic extract of neem increased body weight, feed conversion ratio, decreased mortality rate from different microbial diseases.it also helped to maintain normal biochemical parameter for better health life of chicken. Neem extract increased leukocyte counts and decreased total viable count of bacteria in cecal faeces. Methanol extracts of varying concentrations 1.0, 1.5, 2.0 and 2.5% was prepared and tested against test organisms using agar diffusion method. Gentamicin of same varying concentrations was used to compare the effect of antimicrobial activity of methanol leaf extract. Data revealed that methanol extract of Neem has shown highest antimicrobial activity. Leaf extract of A. indica (Neem) had exhibited a potent antibacterial activity against various strain (E. coli, Salmonella spp) of bacterial pathogens, it showed almost nearest to microbial activity of gentamycin.
 Res. Agric., Livest. Fish.6(2): 337-343, August 2019
Highlights
The poultry production systems have led to marked increase in the production of poultry meat and eggs throughout the world (Armstrong, 1986)
Neem leaves extract has immunostimulant effect that activates the cell mediated immune response and creates an enhanced response to any future challenges occurred by disease organisms
The feeding neem leaves to immunosuppressed birds increased their humoral and cell mediate immune responses (Sadekar et al, 1998)
Summary
The poultry production systems have led to marked increase in the production of poultry meat and eggs throughout the world (Armstrong, 1986). Many synthetic drugs and growth promoters are supplemented to the broilers to effect rapid growth, but their use have shown many disadvantages like high cost, adverse sideeffect on health of birds and long residual properties etc. Neem promotes growth and feed efficiency of birds because of their antibacterial properties (Prasannabalaji et al, 2012). Neem leaves extract has immunostimulant effect that activates the cell mediated immune response and creates an enhanced response to any future challenges occurred by disease organisms. The feeding neem leaves to immunosuppressed birds increased their humoral and cell mediate immune responses (Sadekar et al, 1998). Considering the facts, the objectives of the present study was to evaluate the growth performance of broilers supplemented with neem leaf extracts and to determine the effect of neem leaves extracts in broiler diets as a possible alternative to antibiotic feed additives. The antimicrobial activity of neem leaves against pathogenic bacteria (Escherichia coli, Salmonella typhimurium etc.) was investigated
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