Abstract
Three known compounds, 2-hexylidene-3-methylsuccinic acid ( 1), cytochalasin Q ( 2), and 5-carboxymellein ( 3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester ( 4) and an ophiobolane sesterterpene named halorosellinic acid ( 5), were isolated from culture broth of the marine fungus Halorosellinia oceanica BCC 5149. Compounds 1– 3 exhibited moderate cytotoxicity against KB and BC-1 cell lines with IC 50 values of 1–13 μg/mL, while compounds 2, 3, 5, and 6 showed antimalarial activity with respective IC 50 values of 17, 4, 13, and 19 μg/mL. Halorosellinic acid ( 5) possessed only weak antimycobacterial activity with the minimum inhibitory concentration of 200 μg/mL.
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