Abstract
Purpose: To investigate the in vivo antiplasmodial effect of Mangifera indica aqueous extract in Plasmodium berghei-infected mice, and to characterize its phytochemical constituents and their mechanism of action.
 Methods: The plant leaves (250.71 g) and stem bark (509.34 g) were weighed, macerated in 5 L of boiled, distilled water for 72 h, and filtered. In vivo antiplasmodial evaluation of the extract was carried out using Plasmodium berghei-infected mice. The leaf and stem bark extracts were subjected to gas chromatography-mass spectroscopy (GC-MS) analysis for characterization of their chemical constituents.
 Results: The leaf/stem bark (1:2) extract (88.27 %) exhibited chemosuppressive activities that was better than artesunate (88.04 %) and artemisinin-based combination therapy (ACT, 84.60 %). Its schizonticidal activities (98.63 %) revealed a better therapeutic response when compared with artesunate (92.34 %). Spectroscopic analysis showed linoleic acid esters and other compounds.
 Conclusion: Therapeutic response of leaf/stem bark (1:2) extract exhibit superior schizonticidal activity to ACT and artesunate. Furthermore, the linoleic acid esters in Mangifera indica aqueous extract may contribute to strong antimalarial activity by inhibiting fatty acid biosynthesis.
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