Abstract
The antiinflammatory properties of triterpenoids and steroids from both Ganoderma lucidum and Ganoderma tsugae were studied. Twelve compounds, including ergosta-7,22-dien-3β-ol ( 1), ergosta-7,22-dien-3β-yl palmitate ( 2), ergosta-7,22-dien-3-one ( 3), ergosta-7,22-dien-2β,3α,9α-triol ( 4), 5α,8α-epidioxyergosta-6,22-dien-3β-ol ( 5), ganoderal A ( 6), ganoderal B ( 7), ganoderic aldehyde A ( 8), tsugaric acid A ( 9), 3-oxo-5α-lanosta-8,24-dien-21-oic acid ( 10), 3α-acetoxy-5α-lanosta-8,24-dien-21-oic acid ester β- d-glucoside ( 11), and tsugaric acid B ( 12), were assessed in vitro by determining their inhibitory effects on the chemical mediators released from mast cells, neutrophils, and macrophages. Compound 10 showed a significant inhibitory effect on the release of β-glucuronidase from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB) whereas compound 9 significantly inhibited superoxide anion formation in fMLP/CB-stimulated rat neutrophils. Compound 10 also exhibited a potent inhibitory effect on NO production in lipopolysaccharide (LPS)/interferon-γ (IFN-γ)-stimulated N9 microglial cells. Moreover, compound 9 was also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, which indicated 9 could protect keratinocytes from photodamage.
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