Abstract
Anti-inflammatory Potential of a Novel Imidazole Containing Murrayanine Based Chalcone
Highlights
Murrayanine is an active carbazole compound present in the Indian Curry tree, known as Murraya koenigii L. belonging to the family Rutaceae [1]
The current effort involved screening the significance of imidazole function present in the ring-B of the murrayanine-chalcone scaffold and their further optimization thereof with emphasis on structural aspects
Same-sex albino rats of 5-6 weeks age, having body weight range of 140-230g were taken for the experiment after getting permission from the Department Ethical Committee (DEC) as well as CPCSEA (1389/a/10/CPCSEA)
Summary
Murrayanine is an active carbazole compound present in the Indian Curry tree, known as Murraya koenigii L. belonging to the family Rutaceae [1]. Murrayanine is the extremely investigated molecule due to the simplicity of the chemical characteristics, an application template promoting semi-synthesis, facilitates substitution at multiple sites, and its resultant therapeutic aspects, etc [4]. Murrayanine was explored exhaustively for developing several promising semi-synthetic derivatives or hybrid compounds rationally with enhanced pharmacological effect, reduced toxicity, and better target modulator perspective. The present research involved the synthesis of (E)-3-(4-(1H-imidazol-1-yl)phenyl)-1(1-methoxy-9H-carbazol-3-yl)prop-2-en-1-one from murrayanine and 4-(imidazol-1-yl)acetophenone and exploring the antiinflammatory activity of the fabricated hybrid. The current effort involved screening the significance of imidazole function present in the ring-B of the murrayanine-chalcone scaffold and their further optimization thereof with emphasis on structural aspects
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