Anti-inflammatory Effects of Quranic Plants’ Mixture: A New Pharmaceutical Product

Abstract

Aims: This work was carried out to determine anti-inflammatory effects of this new pharmaceutical product (Quranic Plants’ Mixture) and also to study side effects of this product on many important organs of the body of investigated animals.Place and Duration of the Study: In vivo studies were carried out in the Animal House of the National Research Centre, Dokki, Giza, Egypt (during 21-22 July 2014). Histological studies of investigated animals were done in the Pathology Department Lab, Theodor Bilharz Research Institute, Giza, Egypt.Study Design: Three different doses of this new pharmaceutical product were tested in this study regarding their anti-inflammatory effects.Methodology: In vivo studies of anti-inflammatory effects of feeding adult female albino rats under investigation with three different doses (2, 4 and 8 g/kg ) of this new pharmaceutical product were carried out after 24 hours of inducing inflammation by injecting investigated animals with carrageen. Additionally, weights of many important organs (Brain, Kidney, Liver, Heart, Lung, Spleen, Stomach and Colon) of the body of investigated animals were measured, along with investigations of their histological structures, to examine any bad side effects of this new pharmaceutical product on investigated animals.Results: In vivo studies of anti-inflammatory effects of feeding adult female albino rats under investigation with three different doses (2, 4 and 8 g/kg ) of this new pharmaceutical product showed that, both edema sizes and weights were decreased in case of feeding these rats with all investigated doses of Quranic plants’ mixture. In this regard the highest anti-inflammatory effect was obtained by feeding animals with 8 g/kg of Quranic plants’ mixture based on edema weight estimation; however, 2 g/kg of Quranic plants’ mixture was found to be the best effective dose by estimating edema sizes of inflammated rats. Weights’ estimation and histological investigations of many important organs of the body of investigated animals revealed that, all investigated doses (2, 4 and 8 g/kg ) of Quranic plants’ mixture have not any bad side effects on many important organs of all examined rats.Conclusion: These promising results of anti-inflammatory effects of Quranic plants’ mixture will add a new safe anti-inflammatory agent in the world of pharmaceutical products; also these results will lead us to more biological and chemical investigations of this new, cheap and safe pharmaceutical natural product of plant origin.