Abstract
Two undescribed lignans (7′R,8′R,8S)-4,4′,5,9,9′-pentahydroxy-3,3′,8-trimethoxy-2,7′-cyclolignan (1) and (8S,7′S,8′S)-4-[(4-hydroxy-3-methoxyphenyl)-methyl]-4-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyltetrahydrofuran (2) were isolated from Potentilla anserina L., Rosaceae, together with three known lignans, (+)-cycloolivil (3), (+)-lyoniresinol (4), and (+)-cycloolivil-6-O-β-D-glucopyranoside (5), which were reported for the first time from Potentilla spp. Their structures were determined on the basis of various spectroscopic methods (1D and 2D NMR, MS) and by comparison with the published NMR data. In addition, the absolute configurations of 1 and 2 were confirmed by comparison of the experimental and calculated electronic circular dichroism data. Furthermore, the anti-inflammatory activities of compounds 1–5 were assayed on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells, and their cytotoxic activities to lung adenocarcinoma A549 tumor cell line were evaluated. It was found that compounds 2, 3, and 5 showed moderate anti-inflammatory and cytotoxic activities.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
