Abstract
Aim:The purpose of the present study was to determine the potential of Jatropha curcas latex in the cream formulation on CD68 immune expression (macrophages) during inflammatory phase wound healing process in mice skin.Materials and Methods:Amount of 12 two-months-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. The mice were allotted into four groups of each, entire surface of each group wound covered by base cream control, sulfadiazine 0.1% cream, J. curcas latex cream 10% and, 15%, respectively. All experiments were performed twice a day for 3 days. The wound healing was assayed in stained histological sections in immunohistochemical of the wounds. CD68 expression was investigated under a microscope.Results:The results showed that the cream from the 10% and 15% latex of J. curcas revealed moderate immune reaction to CD68 on wound healing.Conclusion:We concluded that the latex cream of J. curcas possesses anti-inflammatory activity in wound healing process of mice skin.
Highlights
On the basis of the physiology of wound healing, the wounds can be classified as chronic and acute wounds
We concluded that the latex cream of J. curcas possesses anti-inflammatory activity in wound healing process of mice skin
The results of the present study showed that the cream from the 10% and 15% latex of J. curcas revealed moderate immune reaction to CD68 on wound healing
Summary
On the basis of the physiology of wound healing, the wounds can be classified as chronic and acute wounds. Balqis et al [1] documented that chronic wound appeared in an 18-years-old male Elephas maximus sumatranus due to surgical debridement to remove tumor extraskeletal fibrosarcoma in the captive elephant. Acute wounds caused by accidental tripping have been found in wild animals such as tiger, Panthera tigris sumatrae [2]. These wounds contribute to substantial morbidities such as increased risk for infection, limb amputation, and animal death. It is understood that there are certain essential drugs present in modern medicine that help in the healing of wounds.
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