Antiimplantation activity of petroleum ether extract of leaves of Cayratia trifolia Linn. on female Albino rat

Abstract

ObjectiveTo evaluate the antiimplantation properties of the Pet ether extract of leaves of Cayratia trifolia Linn (C. trifolia) in rat by observing the implants after dosing the test extract. MaterialsPregnant females were separated and divided into thirteen groups each containing six animalsand were given Tween-80, 2% v/v. prepared extracts (PEECT) at the dose of 250 mg/kg and 500 mg/kg respectively. All the extracts and vehicle were administered orally to the animals once daily throughout 7 days of pregnancy. On 10th day of pregnancy, the animals were laparotomized under light ether anaesthesia and number of implants present in both the uterine horns was counted. Each pup was weighed and examined for gross defects. ResultAmong the two doses of PEECT, a dose of 500 mg/kg was found to be significant (P<0.01) and percentage inhibition of implantations in rats, at doses of 250 and 500 mg/kg, were found to be in PEECT 37.1, 56.7 respectively when compared with control. The highest activity was observed with the 500 mg/kg dose when the implantation were calculated about 10th day after the administration of the test extracts. ConclusionsIt can be concluded from the study that the Petroleum ether extract of C. trifolia Linn. leaves have potent antiimplantation activity.