Abstract
Of our ethnobotanic investigations in the district of Franceville, on 30 requested people, 20 answered the survey questionnaire. The present study aims at evaluating the hypotensive activity of Nephrolepis biserrata (NB) used by Ndoumou in the province of Haut-Ogooue in Gabon to treat or prevent against arterial hypertension. The Phytochemical studies show that the aqueous foliar extract of Nephrolepis biserrata consists of phenolic constituents, terpeniques and nitrogenous. This extract was used to realize all the tests of our study. The contraction is recorded by a system of isolated organ. NB (5-200 mg/ml) provoke the decrease of the contraction of the aorta of the toad induced by the norepinephrine (10-6 M) in presence and in absence of the endothelium. The threshold of the effect is 5 mg/ml in the presence and 50 mg/ml in absence of endothelium; a maximal decrease is observed in 200 mg/ml. The acetylcholine (10-11-10-7 M) decreases the contraction of the aorta caused by the norepinephrine (10-6 M) in the presence of the endothelium; 3.10-11 M is the threshold of the effect and 10-7 M the maximum, whereas in the absence of endothelium, we observe an increase of the contraction. Nephrolepis biserrata (5-200 mg/ml) cause the reduction of the contraction induced by the norepinephrine (10-6 M) of the aorta pretreated with a solution of L-NAME (10-5 M), in the presence of endothelium; the threshold of the effect is 5 mg/ml and maximum to 200 mg/ml, so highlighting the antihypertensive potential of Nephrolepis biserrata, and those this in presence and in absence of endothelium.
Highlights
Nowadays, because of the weakness of the economic resources, the populations in developing countries often turn to the traditional therapeutic practices (Pharmacopeia).To accompany these populations, the World Health Organization (WHO) in set up a development project of the strategies which would involve the role of the African traditional medicine.According to the WHO, 60% of the current diseases would be due to medicine of synthesis.Supports of the WHO in the herbal medicine as the appeal possible for medicine current, opens new ways of studies for numerous plants
The threshold of the effect is noted to 5 mg/ml (1,70%) and maximum with 200 mg/ml (87,66%); the ED50 is of 100 mg/ml, that is to say a reduction of 51,49%. These results show that Nephrolepis biserrata causes its hypotensive effect by other mechanisms which would not imply only the way of the production of nitric oxide (NO), because in spite of the inhibition of this one by -nitro-arginine methyl ester (L-NAME) (10-5M), the aqueous extract always causes by the action of its compounds, the reduction of the contraction induced by the norepinephrine (10-6 M)
This study shows that the aqueous extract of Nephrolepis biserrata decreases in manner proportions increasing, the contraction of the aorta of the heart of clamping plate; and this in presence and absence of endothelium
Summary
Because of the weakness of the economic resources, the populations in developing countries often turn to the traditional therapeutic practices (Pharmacopeia).To accompany these populations, the World Health Organization (WHO) in set up a development project of the strategies which would involve the role of the African traditional medicine (confer: Strategy of the African region AFR/RC50/9; 2010).According to the WHO, 60% of the current diseases would be due to medicine of synthesis.Supports of the WHO in the herbal medicine as the appeal possible for medicine current, opens new ways of studies for numerous plants. Because of the weakness of the economic resources, the populations in developing countries often turn to the traditional therapeutic practices (Pharmacopeia). To accompany these populations, the World Health Organization (WHO) in set up a development project of the strategies which would involve the role of the African traditional medicine (confer: Strategy of the African region AFR/RC50/9; 2010). Studies were led to highlight the use of certain plants in the treatment of the high blood pressure in Africa. In Ivory Coast, the populations use the aqueous solutions of the leaves of Citrus aurantifolia (Rutaceae) to handle the high blood pressure [1,2,3]
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