Abstract
Plasma immunoreactive prostaglandin E (iPGE) levels during PGE 1 infusion for controlling systemic blood pressure were investigated. Differences in systemic blood pressure changes between halothane-nitrous oxide-oxygen (GOF) anesthesia groups and a neuroleptanesthesia (NLA) group during infusion in hypertensive surgical patients were compared. Plasma iPGE concentration increased from 200 ± 30 pg/ml to 408 ± 55 pg/ml within 5 minutes at the beginning of PGE 1 infusion. After the cessation of PGE 1 infusion, iPGE levels quickly returned to pre-infusion levels, but blood pressure had not recovered to pre-infusion levels within 30 minutes. Blood pressure was well controlled with PGE 1 infusion, but the pressure changes in GOF anesthesia group were significantly larger than those in the NLA group. The results suggest that the long anti-hypertensive action of PGE 1 could be effective to control blood pressure in hypertensive surgical patients during and after surgery.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
