Abstract
Background It is well documented that biologically active components of microalgae can be utilized for treatment of different diseases. This study was conducted to evaluate the antihyperglycemic and antihyperlipidemic activities and weight control of Nannochloropsis oculata microalgae (NOM) in Streptozotocin-induced diabetic male rats. Methods Diabetes was induced by intraperitoneal administration of Streptozotocin (55 mg/kg). Healthy and diabetic rats were divided in to six groups. Healthy and diabetic rats orally received distilled water or NOM (10 and 20 mg/kg) for three weeks. Results Oral administration of NOM to diabetic rats significantly reduced the serum concentrations of glucose, cholesterol, triglycerides, LDL and increased the serum concentration of insulin and HDL-C (P<0.05). Treatment with NOM had no significant effect on blood parameters in healthy rats (P>0.05). Also, NOM maintained body weight in diabetic rats (P<0.05). Conclusion It can be concluded that NOM has antihyperglycemic and antihyperlipidemic activities in diabetic rats.
Highlights
Introduction ofNannochloropsis oculata microalgae (NOM) in structure have been extensively considered for treatmentStreptozotocin-induced diabetic male rats.of diabetes because they decrease the risk of chronic
Our findings show that the serum concentrations of glucose, insulin, triglycerides, cholesterol, LDL-C and HDL-C were not influenced by NOM administration in healthy rats (Tables 3 and 4; P>0.05)
Significant differences were seen between diabetic rats and healthy rats for total protein, albumin, alkaline phosphatase, aspartate amino transferase and alanine amino transferase (P
Summary
Nannochloropsis oculata microalgae (NOM) in structure have been extensively considered for treatment. Of diabetes because they decrease the risk of chronic. Diabetes is one of most common cause of death in the world, that is mainly caused by persistent hyperglycemia the activity of EePAxaamndplDeHs A(ii[i1)4,,(1iv5)] dauree stopeitcsianl tciaosxeidsaonft(v). ©Th2i0s1w9oKrakzuismlaicseanNsoemdura and Paul Terwill under the Creative Commons Attribution-NonCommercial NoDerivatives 4.0 License. 38 Fariba Nasirian et al Antihyperglycemic and antihyperlipidemic activitie of Nannochloropsis oculata. This study aimed to evaluate the antihyperglycemic or antihyperlipidemic activities of NOM in healthy and diabetic rats. It is well documented that Reactive oxygenKespyewcoiersds(R:OLSe)onaraerdprpoadiur,cetrdidiniagdoianbaeltems atrix, self-dua biologically active components of microalgae can be utilized for treatment of different diseases. This study mpreoldliutuctss[3s]u.cThodCaaslyahsreserisbescaaractnhiodenrsa:la1g7raeBe3tr7yw,i1nh5gicAht2o1cfainndbneatuusreadl was conducted to evaluate the antihyperglycemic to normalize the blood glucose and dyslipidemia in and antihyperlipidemic activities and weight control diabetes mellitus.
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