Antihyperglycemic and antidyslipidemic Effect of Moricandia suffruticosa in Normal and Streptozotocin-Induced Diabetic Rats.

Abstract

The present work aimed to assess the antihyperglycemic and antohyperlipidemic effects ofMoricandia suffruticosa. Moricandia suffruticosa (M. suffruticosa) is used in traditional medicine. The present study investigated the antihyperglycemic and antidyslipidemic effects of M. suffruticosa and its effect on glycogen content in normoglycemic and hyperglycemic rats. The effect of the aqueous extract of M. suffruticosa (AEMS) at a two doses of 100 and 140 mg/kg on blood glucose levels, lipid, lipoprotein profile, and glycogen content was examined in normal and streptozotocin(STZ)-induced diabetic rats. On the other hand, a preliminary phytochemical screening and quantification of phenolic, flavonoid, and tannin contents were carried out. The results demonstrated that AEMS exhibits antihyperglycemic activity in diabetic rats during both acute and subchronic essays. Furthermore, AEMS revealed an antidyslipidemic effect concerning the level of triglycerides, total cholesterol, very-low density lipoprotein (VLDL), and non-high density lipoproteins (Non-HDL). In contrast, AEMS has not affected the value of glycemia, lipids, and lipoproteins in normal rats. In addition, AEMS is rich in several phytochemical compounds. Furthermore, AEMS revealed an important in vitro antioxidant activity. In conclusion, the study demonstrates that M. suffruticosa exhibits an important antihyperglycemic effect in diabetic rats.