Abstract
Abstract The availability of similarly prepared hexon antigen vaccines of three different serotypes of adenovirus (types 1, 2 and 5) provided the opportunity to systematically examine the responses in man to several variables of subunit vaccine and vaccination. Each of the vaccines exhibited differing antigenicity for guinea pigs and was available as an aqueous and an adjuvant preparation. In addition to examining the effect of these variables of the vaccine, the effect of one and two injections and route of inoculation were also examined. Recent studies with diphtheria toxoid in aqueous and adjuvant form have suggested that the physical state of antigen is of paramount importance for development of 11S IgA secretory antibody (1). In those studies, the aqueous diphtheria toxoid preparation stimulated secretory antibody following topical as well as parenteral administration. However, when adjuvant vaccine was given parenterally, volunteers developed high serum antibody titers but no 11S IgA secretory antibody and when given topically this vaccine was apparently non-antigenic.
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