Abstract
Nine n-hexane extracts of plant materials selected on the basis of medicinal folklore for skin disease treatment in Aceh were studied for their activity in inhibiting Candida albicans. Phytochemical analysis majority sampel revealed the presence of secondary metabolites alkaloids and saponins in the plants thus indicating the therapeutic potentials of the plant. The results of screening indicated that three of n-hexane extracts Calotropis gigantean Willd, Capsicum frutescens L, and Centella asiatica (L.) Urban were contain active compounds that inhibit mast-cell degranulation to C. albicans. Nystatine used as standard reference. Centella asiatica (L.) Urban gaves the largest inhibition to C. Albicans among the samples, the concentration of 1, 5 and 10% inhibits 9, 10, and 12 mm, respectively. The isolated compounds n-hexane extract from Centella asiatica were identified by using Gas Chromatography Mass Spectroscopy. The result showed the presence of bicyclo [3.1.1]Heptena,2,6,6-trimethyl, [1.alpa,2.Beta,5.alpa] amount 21.55%, 1,6,10-odecatriene, 7,11dimethyl-3-methylene amount 20.55%, quinoline, 2,3-dimethyl amount 13.49%, and acid 1,2benzenedicarboxylate, mono (2-ethylhexyl) ester amount 9.92%.
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