Abstract
This work aimed to evaluate the antifungal activity of piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The mice (n = 6) were infected by intraperitoneal injection of 0.2 ml of C. albicans (107cells/ml in saline). The animals were observed daily for clinical signs and mortality for 14 days. The treatment with piroctone olamine (0.5 mg/kg) was performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n = 6) was treated with amphotericin B (0.5 mg/kg). The mycological diagnosis was made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality were analyzed statistically by Student’s t test and analysis of variance (ANOVA), with level of significance set at P < 0.05. The difference in fungal growth scoring between the control group and the treatment groups (piroctone olamine and amphotericin B) was statistically significant (P < 0.05). The difference in fungal growth scoring between the treatment groups (piroctone olamine and amphotericin B) was not statistically significant (P < 0.05).
Highlights
Piroctone olamine (1-hydroxy-4-methyl-6-(2,4,4-trimethyl)2-(1H)pyridinone,2-aminoethanol salt) is an ethanolamine salt of the hydroxamic acid derivative piroctone
This work aimed to evaluate the antifungal activity of piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice
The isolates were less susceptible to fluconazole (FLZ), for which the minimum inhibitory concentrations (MICs) ranged from 0.5 to 64 μg/mL
Summary
Piroctone olamine (1-hydroxy-4-methyl-6-(2,4,4-trimethyl)2-(1H)pyridinone,2-aminoethanol salt) is an ethanolamine salt of the hydroxamic acid derivative piroctone. This antifungal compound was first synthesized in 1979 by Schwarzkopf-Henkel (Germany) (Kim et al 2011). It is a component of many cosmetic products such as anti-dandruff shampoo and hair rinses for scaly and irritated skin. One reason for scaling and irritation of the scalp is the colonization with Malassezia spp. and other yeasts. These microorganisms split parts of the sebum of the capillitium lipolytically into free fatty acids.
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