Formulation, Development and Evaluation of Anti-Dandruff Shampoo using Piroctone Olamine

Abstract

The aim of this study was to formulate and develop anti dandruff shampoo by determining the antifungal activity of Piroctone olamine as well by agar diffusion method based on zone of inhibition. Piroctone olamine, also known as Octopirox and piroctone ethanolamine, is a compound reported to be used in the treatment of fungal infections. Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone. In this study, shampoo was formulated using various concentrations of Piroctone olamine. Piroctone olamine and shampoo formulations containing Piroctone olamine were evaluated for antifungal activity against Malassezia furfur (1374) and Candida albicans. The results showed that Piroctone olamine and shampoo formulation containing Piroctone olamine is effective against the microorganisms responsible for dandruff. Keywords: Dandruff, Piroctone olamine Cite this Article: S. M. Gadegone, K. S. Misar, B. Ingle. Formulation, Development and Evaluation of Anti-Dandruff Shampoo using Piroctone Olamine. International Journal of Biochemistry and Biomolecules. 2019; 5(1) 1–5p.