Abstract
Synthesis and Antimicrobial studies of novel Benzimidazole derivativesParmender Singh Rathee,Ritu Dhankar, Sunny Bhardwaj,Monika Gupta, Rakesh Kumar
Highlights
Cryptococcosis is an opportunistic fungal infection that has featured between mycoses due to its high incidence in patients with Acquired Immunodeficiency Syndrome (AIDS), and the difficulties of treatment, high mortality in humans and animals with nervous system involvement central.Cryptococcus neoformans is a major etiological agents of cryptococcosis, and has the ability to infect healthy individuals and with impaired cellular immunity (Chayakulkeeree and Perfect 2006; Dromer et al, 2004; Mirza et al, 2003; Pukkila-Worley and Mylonakis, 2008; Singh et al, 2008)
The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC / MS) and minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were determined by the broth micro dilution techniques
Company Quinarí® House of Essences (Ponta Grossa, Parana, Brazil), being extracted from the leaves by steam distillation. This product has met the purity requirements specified by the Food and Agriculture Organization (FAO) and the World Health Organization (WHO) on food additives and their quality parameters were described in a technical bulletin sent by the company
Summary
Cryptococcosis is an opportunistic fungal infection that has featured between mycoses due to its high incidence in patients with Acquired Immunodeficiency Syndrome (AIDS), and the difficulties of treatment, high mortality in humans and animals with nervous system involvement central.Cryptococcus neoformans is a major etiological agents of cryptococcosis, and has the ability to infect healthy individuals and with impaired cellular immunity (Chayakulkeeree and Perfect 2006; Dromer et al, 2004; Mirza et al, 2003; Pukkila-Worley and Mylonakis, 2008; Singh et al, 2008) Since the treatment this mycosis, involves a therapeutic system with limited antifungal agents, some of these, with high toxicity and microbial resistance (Girois et al, 2006). It is widely used by the food industry, pharmaceuticals and cosmetics
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