Abstract
The aim of present study was to evaluate the effect of single oral doses of triptolide on fertility of male house rat, Rattus rattus. Single oral administration of triptolide to male R. rattus resulted in 16.67 and 33.33% mortality in rats treated with 100 and 150 mg kg−1 b.wt. of triptolide, respectively, within 1–3 days of treatment. The LD50 value of triptolide against male R. rattus was found to be 182.81 mg kg−1 b.wt. Autopsy of rats surviving till day 45 after treatment revealed no significant effect on weights of reproductive organs. The sperm motility and viability in cauda epididymal fluid were reduced significantly in all the treated groups. Sperm concentration was significantly reduced only in rats treated with 100 mg kg−1 b.wt. of triptolide. Treatments significantly affected sperm morphology. The sperms with head tail separation ranged from 15.8 to 24.0% in all treated groups. The present study suggests the potential of triptolide in regulating fertility of male R. rattus.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
