Abstract
The effects of dihydroartemisinin on epididymal sperm characteristics and testosterone levels in male albino rats were studied. Dihydoartemisinin treatment for 7 days and 21 days in the rats resulted in a decrease in the sperm count, sperm motility and sperm viability. The abnormalities noticed in sperms werecurved mind pieceand small and pyriform heads observed only in some groups. The sperm motility, disability and counts were significantly reduced in all the treated groups when compared with the control and the reductions were both dose and duration dependent. There was a significant decrease in serum testosterone levels in rats treated with an initial dose of 4.4mg/kg body weight of dihydroartemisinin (P< 0.05) when compared with control. These observations suggest that the effects are probably due to an androgen deficiency caused by the anti-androgens property of the dihydroartemisinin.
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