Abstract
Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus (CRV) possess a high phenolic compound content with excellent antioxidant activity. Dietary antioxidants can reduce exercise-induced oxidative stress. Consumption of large amounts of phenolic compounds is positively correlated with reduction in exercise-induced muscle damage. Research for natural products to improve exercise capacity, relieve fatigue, and accelerate fatigue alleviation is ongoing. Here, CRV containing a large total phenolic content (13.4 mg/g of CRV) demonstrated antioxidant activity. Ultra-performance liquid chromatography quantification revealed 1.95 ± 0.02 mg of salidroside in 1 g of CRV. In the current study, CRV were administered to mice for five weeks, and the antifatigue effect of CRV was evaluated using the forelimb grip strength test; weight-loaded swimming test; and measurement of fatigue-related biochemical indicators, such as blood lactate, ammonia, glucose, blood urea nitrogen (BUN), and creatine kinase (CK) activity; and muscle and liver glycogen content. The results indicated that in CRV-treated mice, the forelimb grip strength significantly increased; weight-loaded swimming time prolonged; their lactate, ammonia, BUN, and CK activity decreased, and muscle and liver glucose and glycogen content increased compared with the vehicle group. Thus, CRV have antifatigue activity and can increase exercise tolerance.
Highlights
Fatigue is one of the most common physiological reactions
The supplement was extracted from Calendula officinalis, Ribes nigrum and Vaccinium myrtillus and provided from HOCKSHENG Trading Co., LTD (Taipei City, Taiwan)
The results indicated that there were no significant differences in the liver, muscle, kidney, heart, lung, epididymal fat pad (EFP), and brown adipose tissue (BAT) among the vehicle and CRV-treated groups (p > 0.05), and the relative organ weight adjusted by individual weight revealed similar results
Summary
Fatigue is one of the most common physiological reactions. The main physiological effect of fatigue is on the energy metabolism during muscle activity [1]. Endurance exercise has a positive effect on antifatigue activity [1]. Scientists are seeking natural products that can improve exercise capacity, and relieve fatigue and accelerate fatigue alleviation without side effects [2]. Fatigue is the loss of normal performance during an athletic activity or exercise and is often associated with tissue damage and energy imbalance. Recovery from fatigue depends on various modes of challenge and treatment. Few studies have investigated the effects of functional plant extracts on exercise performance and antifatigue activity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
