Abstract
Correlations were investigated between plasma levels of antidiuretic hormone (ADH) and the frequency of vertigo attacks, and between hearing and serum Na levels in patients with Meniere's disease. Plasma ADH levels were measured every 3 months for 1 year in 48 patients. Those with persistently high plasma ADH levels tended to have frequent vertigo attacks (Fischer's exact probability test; P<.05). However, serum Na levels and pure tone average (PTA) levels showed no correlation with plasma ADH levels. These results, together with those of the previous study by the present authors, which showed a close correlation between plasma ADH levels and a positive glycerol test and ECoG, suggest that high plasma ADH levels in patients with Meniere's disease have a pathologic mechanism different from that of SIADH.
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