Correlations of Glycerol Test and Electrocochleogram with the Value of Plasma ADH

Abstract

Glycerol test results and electrocochleographic (EcochG) findings were correlated with the plasma antidiuretic hormone (ADH) level in patients with Meniere's disease. There was no statisticaly significant correlation between the glycerol test and plasma ADH. However, the plasma ADH level tended to decrease in patients with a positive reaction to the glycerol test and tended to increase in patients with a negative reaction. There was a statisticaly significant correlation between the dominant negative SP (-SP) of EcochG and the plasma AD H level. Plasma ADH tended to increase in patients with dominant -SP. It has been reported that the plasma ADH level in patients with Meniere's disease is higher than normal. Both the positive reaction to the glycerol test and the dominant -SP of the EcochG indicate the presence of endolymphatic hydrops. In this study, however, there seems to be a discrepancy between the correlations of glycerol test result and EcochG with the plasma ADH level. These results may mean that the positive reaction to the glycerol test and the dominant -SP of EcochG may represent different conditions of endolymphatic hydrops in Meniere's disease.