Abstract
The ethanolic bark extract of Mitragyna diversifolia showed significant (p<0.05) antidiarrheal activity on gastrointestinal motility with barium sulfate milk model and castor oil- induced diarrheal model in rats. These result obtained revealed that the bark extract possess pharmacological activity against diarrhea and may possibly explain the use of the plant in traditional medicine.
Highlights
Diarrheal diseases are one of the leading causes of morbidity and mortality in developing countries and are responsible for the death of millions of people each year (Carlos and Saniel, 1990)
M. diversifolia bark extract significantly (p
M. diversifolia bark extract significantly (p
Summary
Diarrheal diseases are one of the leading causes of morbidity and mortality in developing countries and are responsible for the death of millions of people each year (Carlos and Saniel, 1990). Despite immense technological advancement in modern medicine, many people in the developing countries still rely on the healing practices and medicinal plants for their daily health care needs (Ojewole, 2004). The World Health Organization encouraged studies for the treatment and prevention of diarrheal diseases depending on traditional medical practices (Atta and Mouneir, 2004). The bark of the plant is used traditionally by Bawm community of Bandarban district as remedy for diarrhea but has not been investigated for its antidiarrheal activity. The purpose of the present study was to find out the antidiarrheal activity of ethanolic bark extract of M. diversifolia in experimentally-induced acute diarrhea in rats
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