Abstract
Providing scientific evidences for the medicinal benefits and possible toxic effects of the flamboyant flowers (Delonix regia (Bojer ex Hook.) Raf.) are very important to implementing the medicinal plant in this modern era. This study aimed to investigate antidiabetic potential of methanol extract of flamboyant flowers using a completely random design. Twenty-four male rats were randomly divided into 6 treatment groups with 4 replications: healthy rats (normal control, P1), diabetic rats treated with flamboyant flower extract of 0 (negative control, P2), 100 (P3), 200 (P4), and 400 mg/kg BW (P5), and rats which were induced by 0.45 mg/kg BW of Glibenclamide (positive control, P6). Diabetic condition was achieved by a single injection of alloxan 150 mg/kg BW. Treatments were given once a day for 14 days. On day 0, 3 and 18 blood samples were withdrawn from rats’ orbital vein for glucose measurement. All rats were sacrificed for liver, gastrocnemius muscles and pancreatic tissues collection. The liver and gastrocnemius muscle were subjected for glycogen measurement whereas pancreatic tissues were processed for histological examinations. Data was analyzed by ANOVA and followed by Duncan test. The results showed that flamboyant flowers extracts significantly (p<0.05) reduced blood glucose as well as degeneration and necrosis of pancreatic β cells. Optimal dose to decrease blood glucose and pancreatic cell degeneration was 200 mg/kg BW; whereas optimum dose to decrease pancreatic cell necrosis was 400 mg/kg BW. In conclusion, flamboyant flower extract can reduce blood glucose in rats. This is the first that shows antidiabetic potential of local Flamboyant flower extracts along its toxicity effect to pancreatic tissues. These information could become a basic consideration for the use of the plant extracts as a candidate to cure patients with diabetic problems.
Highlights
Diabetes mellitus (DM) is a chronic hyperglycemic state due to hormonal disorders
The cause of DM is the decrease of insulin hormone produced by β cells of the pancreas that play a role in cell glucose metabolism, causing higher levels of blood glucose and hyperglycemia (Suarsana et al 2010)
The four compounds have the potential to improve heart function (Wang et al 2016), lower blood glucose levels (Lu et al 2021; Al-Ishaq et al 2019), and to Kartini Eriani et al / Biosaintifika 13 (2) (2021): 185-194 cure damage of pancreatic β cells of people suffered from diabetes mellitus (Yeon et al 2015)
Summary
Diabetes mellitus (DM) is a chronic hyperglycemic state due to hormonal disorders. The cause of DM is the decrease of insulin hormone produced by β cells of the pancreas that play a role in cell glucose metabolism, causing higher levels of blood glucose and hyperglycemia (Suarsana et al 2010). The four compounds have the potential to improve heart function (Wang et al 2016), lower blood glucose levels (Lu et al 2021; Al-Ishaq et al 2019), and to Kartini Eriani et al / Biosaintifika 13 (2) (2021): 185-194 cure damage of pancreatic β cells of people suffered from diabetes mellitus (Yeon et al 2015). Another study by Chaturvedi et al (2014) has confirmed antidiabetic potential of aqueous suspension of flamboyant flower leaves extract (100 and 200 mg/kg) in alloxan-induced hyperglycemic rats. Focussing on the blood glucose, tissue glycogen content and pancreatic tissue histology, the present study was carried out to investigate the effect of extract of flamboyant flowers found in Banda Aceh on diabetes using alloxan-induced diabetic rat model. Results obtained may provide a helpful information in the way to study the antidiabetic exploration of the plant extract for the development of antidiabetic formulation
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