Abstract
Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to synthetic drugs. Tinospora cordifolia commonly named as “Guduchi” is known for its immense application in the treatment of various diseases in the traditional Ayurveda literature. The present study was aimed to evaluate the anti-diabetic activity of isolated compounds from aerial parts of Tinospora cordifolia (Guduchi) in alloxan induced diabetic rats. Diabetic wistar albino rats were treated with standard drug Glibenclamide and prepared drug formulation in two different doses 250 mg and 500 mg/kg. Hypoglycemic effect was evaluated in these rats and the efficacy of isolated compounds was administered in alloxan induced diabetic rats. At the end of study period blood glucose level were statistically analyzed based on the results. Isolated compounds produced a significant reduction in blood glucose level when compared with non-treated diabetic rats. So the present research work was confirmed that the isolated compounds possess hypoglycemic effect significantly.
Highlights
Medicinal plant knowledge has usually resulted from trial and error, and was based on speculation and superstition
This trend is reversing in favor of medicinal plants as they contain natural products that are chemically balanced, effective and least injurious with none or much reduced side effects as compared to synthetic chemicals.[1]
Fresh matured aerial parts of Tinospora cordifolia was collected in bulk, initially rinsed thoroughly with distilled water, shade dried for 15 days
Summary
Medicinal plant knowledge has usually resulted from trial and error, and was based on speculation and superstition. In the middle of 20th century, the contribution of medicinal plants was reduced by approximately one fourth as researchers favored the use of synthetic chemicals for curing diseases. This trend is reversing in favor of medicinal plants as they contain natural products that are chemically balanced, effective and least injurious with none or much reduced side effects as compared to synthetic chemicals.[1] Herbal medicine is experiencing a revival in Western society, along with other complementary therapies such as traditional Chinese medicine, Unani, Homeopathy.etc. We have elucidated the possible antidiabetic activity of Tinospora cordifoloa and its medicinal potency responsible for the hypoglycemic activity.[9, 10]
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