Abstract
This paper studies the antidiabetic effects of soluble dietary fiber (SDF) from steam explosion-modified black soybean hull in low-dose streptozotocin- (STZ-) induced type 2 diabetic mouses. Male C57/BL6 mouses were divided into 4 groups: control (nondiabetic, no SDF intake), model (diabetes only), metformin (metformin: 100 mg/kg body weight), and SDF (SDF: 600 mg/kg body weight). Four weeks post-SDF treatment, treatment of SDF decreased the weight gain of diabetic mouses, normalised the blood glucose level, and reduced the serum cholesterol, serum insulin, leptin, glucagon-like peptide, total cholesterol, triglyceride, low-density lipoprotein cholesterol, arteriosclerosis index, aspartate aminotransferase activity, and malondialdehyde. It also increased high-density lipoprotein cholesterol, adiponectin, glycopeptide peroxidase, superoxide dismutase activity and repaired the pancreatic injury of the diabetic mouses. Our research results show that SDF has the potential for use in type 2 diabetes treatment.
Highlights
Diabetes is one of the most common endocrine diseases triggered by insulin secretion deficiency or insulin disorders
Compared to the diabetic model group, the food intake of the metformin and soluble dietary fiber (SDF) groups decreased by 26.58% and 25.29% (p ≤ 0.05), respectively, and there was no significant difference between the food intake of the SDF and metformin groups
Compared to the diabetic model group, the water intake of the metformin and SDF groups decreased by 19.31% and 17.02% (p ≤ 0.05), respectively, and there was no significant difference between the water intake of the SDF and metformin groups
Summary
Diabetes is one of the most common endocrine diseases triggered by insulin secretion deficiency or insulin disorders. Previous studies have suggested that dietary fiber obtained from the consumption of fruits, grains, and beans can increase the content of liver glycogen and inhibit the rise of postprandial blood glucose, as well as increase the activity of superoxide dismutase (SOD) in the serum and liver, reduce the content of malondialdehyde (MDA), and reduce the activity of lactic dehydrogenase (LDH) in the serum and liver so as to effectively protect the heart and liver. We investigated the effects of SDF from steam explosion-modified black soybean hull on body weight, food intake, serum biochemical indices, serum lipids, and histopathological analysis in type 2 diabetic mouses using an experimental mouse model of low-dose streptozotocin(STZ-) induced diabetes. Our collective findings clearly support the therapeutic potential of SDF from black soybean hull on type 2 diabetes
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