Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

Abstract

The effects of soluble dietary fibre (SDF) and insoluble dietary fibre (IDF) from deoiled cumin on low-dose streptozotocin and high glucose-fat-induced type 2 diabetes rats were examined. Male Wistar rats were divided into nine groups: control (non-diabetic, no SDF or IDF intake), model (diabetes only), metformin, high-dose SDF (5 g/kg body weight), middle-dose SDF (500 mg/kg body weight), low-dose SDF (250 mg/kg body weight), high-dose IDF (5 g/kg body weight), middle-dose IDF (500 mg/kg body weight), and low-dose IDF (250 mg/kg body weight). SDF treatments, in particular, middle-dose SDF for 4 weeks, induced better regulation of blood glucose, insulin, hormones, and liver lipid metabolism in diabetic rats, accompanied by increased levels of short-chain fatty acids in colon and decreased fatty degeneration of liver. Our results collectively support the therapeutic potential of SDF from deoiled cumin in type 2 diabetes.