Antidiabetic and antihyperlipidemic activities of extracts of Barleria buxifolia Linn on streptozotocin induced diabetic rats

Abstract

Traditionally, Barleria buxifolia Linn is utilized for antidiabetic action with absence of logical investigation. Thus, the current examination was attempted to explore for its antidiabetic and antihyperlipidemic movement in streptozotocin instigated diabetic animal models. Blood glucose levels were estimated in normoglycemic rats at initial, 60th and 120th minutes intervals and in glucose feed hyperglycemic rats at initial, 30, 60, 90 and 120 minutes after solitary portion of streptozotocin at 55 mg/kg body weight intraperitoneal were made diabetic in albino rats. Blood glucose levels were estimated at week by week spans after every day administration of chloroform and methanol extracts of Barleria buxifolia at dosages of 250 and 500 mg/kg body weight. Other biochemical boundaries of serum triglycerides, cholesterol, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, total protein, albumin, globulin, uric acid, creatinine, urea, transaminases, alkaline phosphatase, alanine aminotransaminase, insulin and glycosylated hemoglobin were likewise estimated toward the finish of the investigation. Chloroform and methanol extracts of Barleria buxifolia by oral organization for 21 days altogether (P<0.001) decreases the elevated blood glucose levels in diabetic rats whereas in normoglycemic rats it doesn’t alter the blood glucose levels significantly and in glucose feed hyperglycemic rats significantly decreases the raised blood glucose levels. Likewise, the chloroform and methanol extracts of Barleria buxifolia improved other biochemical boundaries related with diabetes. Moreover, the extracts of Barleria buxifolia favorable affect the histopathological changes of pancreas in streptozotocin initiated diabetic rats. Delayed consequences legitimize the traditional utilization of Barleria buxifolia for its antidiabetic action. Keywords: Antidiabetic activity, Barleria buxifolia Linn, Biochemical parameters, Histopathology.