Antidiabetic Activity Test of Sambiloto Capsules (Andrographis paniculata) with Glibenclamide on White Male Mice DDY Strain

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and metabolic abnormality of carbohydrates, fats, and proteins caused by decreased insulin sensitivity. Glibenclamid as a synthesis drug or traditional medicine such as Sambiloto Capsule could use for diabetes mellitus. Hereditary, people have been using decoction of Sambiloto’s leaves to prevent cold, influenza, fevers, jaundice. The bitterness of Sambiloto (Andrographis paniculata) was also believed to cure diabetes. The purpose of this research was to compare between Sambiloto capsule with Glibenclamid on white male mices DDY strain. The research method was an experimental study using pre and post test control group design, using 15 white male mices DDY strain which were given a glucose load and divided into 3 groups. Negatif control group (CMC Na), positive control group (Glibenclamid), and test group (Sambiloto Capsules). The results blood glucose level of this research was analyzed using Paired T-test and with the 95 % convidence level. The comparison test of antidiabetes activity between Sambiloto Capsule and Glibenklamid on white male mice DDY strain showed that the Sambiloto Capsule had antidiabetic activity viewed from the average decline in blood glucose levels. The degradation of blood glucose levels in Glibenklamid group was faster than Sambiloto Capsule group indicated by the statistical analysis using Paired T-test with the significance level smaller than 0,05 and showed by T-value was great than T-tabel. Conclusion of the research showed that the activity Sambiloto Capsules anti diabetic.