Antidiabetic Activity of Root Tubers of Cyanotis tuberosa in Streptozotocin Induced Diabetic Rats

Abstract

Diabetes mellitus arising due to insufficient insulin production or its action or both is characterized by hyperglycemia. According to WHO it ranks as the third leading cause of death. Presently available antidiabetic drugs have one or more side effects. There is a need for new antidiabetic agents that will have therapeutic effect with fewer side effects. Cyanotis tuberosa is traditionally used as ethno medicine for curing several ailments in India. The objective of this study was to evaluate the antihyperglycemic activity of root tubers of Cyanosis tuberosa (Commelinaceae) in STZ induced diabetic rats. Different doses of aqueous suspension and different solvent extracts (made by soxhlation) were given to the Streptozotocin induced diabetic rats orally by using oral gavage. After treatment aqueous suspension at the dose of 250 mg/kg b.w has markedly (69%) decreased the fasting blood glucose levels after 6 hours of treatment. Whereas among the solvents extracts hexane extract at the dose of 750mg/kg b.w has produced highest (87%) anti hyperglycemic activity than the other solvent extracts and it is higher than that of the standard drug glibenclamide (20 mg/kg b.w). No hypoglycemic effects were observed in the diabetic rats after the treatment. And Cyanosis tuberosa improves the oral glucose tolerance of diabetic rats when given the hexane extract at the dose of 750mg/kg b.w. Phytochemical analysis of the hexane extract revealed the presence of bioactive secondary metabolites such as flavonoids, tannins, saponins, terpenoids, phenolics, and triterpenes which are responsible for antihyperglycemic activity. In conclusion our findings suggest that the hexane extract of Cyanotis tuberosa can decrease the hyperglycemia in diabetic rats most efficiently without any side effects.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.