Abstract
The present study was aimed to investigate the anti-diabetic activity of Anemarrhena asphodeloides Bge. Polysaccharides (AAP). Wistar rats were injected with streptozotocin(STZ)to induce diabetes. The APP was prepared at first. After the rats were orally administered for 28 days, related biochemical indicator were determined. AAP was composed of mannose, galacturonic acid, galactose, glucose and xylose in the molar ratio of 12:8.1:2.7:1.3:1 with the average molecular weight of 52.4 kDa. After treatment with AAP (100 and 200 mg·kg-1) for 28 days there was a significant decrease in blood glucose, SGPT, SGOT, ALP, TC, TG, LDL, BUN and significant increase in body weight, fasting serum insulin, pancreatic insulin and HDL. The activities of SOD and CAT in liver and kidneys also increased. The results of the experiments showed that AAP exerted significant anti-diabetic activity.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call